SynChem-Formosa: Leaders in Medicinal Chemistry and Custom Synthesis
At SynChem-Formosa, we provide cutting-edge solutions in synthetic organic chemistry, process optimization, bioconjugation, and peptide synthesis. With over 25 years of experience and a commitment to innovation, we deliver quality services tailored to the needs of the pharmaceutical and biotech industries.
Core Values and Services
Process Development
- Scalable and cost-effective synthetic route development.
- Optimization of synthetic routes for complex challenges.
- Custom manufacturing under cGMP conditions for both standard and niche chemical products.
- Solutions for large-scale production with enhanced yields and sustainability.
- Expertise in polymer-based APIs, including:
- Sevelamer Hydrochloride – Serum phosphorus control.
- Colesevelam Hydrochloride – Lipid-lowering polymer.
- Patiromer Sorbitex Calcium – Hyperkalemia treatment.
Bioconjugation
- Mature and advanced ADC manufacturing technologies, including traditional lysine- and cysteine-based conjugation and site-specific conjugation via enzyme catalysis and click chemistry.
- Expertise in precise DAR (Drug-to-Antibody Ratio) control, ensuring high-quality production.
- Flexible manufacturing capabilities, supporting small-scale batches (>20 mg) to large-scale production (~800g) for pre-clinical and clinical studies.
- Development of custom linker and payload synthesis for optimized ADC performance. High-DAR solutions and bioconjugation-ready intermediates for next-generation therapeutics.
- Comprehensive analytical support, covering plasma stability and all CMC (Chemistry, Manufacturing, and Controls) items.
- Polymer drug conjugation and peptide drug conjugation (PDC) services, including custom linker-payload design and cGMP-compliant manufacturing.
Seamless scale-up to GMP production at our facility in Taoyuan, Taiwan.
Peptide Synthesis
- Custom synthesis of linear and cyclic peptides with modifications, including PEGylation.
- Scalable production from research-grade to GMP-level therapeutic peptides.
- Utilization of advanced microwave solid-phase synthesizers for precision and efficiency.
Small Molecule Synthesis and Process chemistry
- Expertise in multi-step synthesis of complex organic molecules and tailored intermediates.
- Specializations include:
- Biaryloxymethylarenecarboxylic Acids – Glycogen synthase activators.
- N-(2-Aminophenyl)-4-(1-Methyl-1H-Indol-3-Yl)Pyrimidin-2-Amine – Cyclin-dependent kinase 2 inhibitor.
- Chiral compounds, stereoselective synthesis, and heterocyclic chemistry.
- Production capabilities:
- Building blocks for click chemistry.
- Catalog compounds and bioactive molecules.
- Full-Time Employee (FTE) services for lead molecule process and analytical method development.
Services available at Taoyuan, Taiwan
We Value
Comprehensive Solutions
From early-stage research to clinical-scale production, SynChem ensures smooth transitions and timely delivery at every stage of drug development.
Commitment to Quality
We uphold rigorous IP protection and meet global quality standards in every project we undertake.
Client-Focused Service
Tailored solutions designed to meet unique project needs, delivered with a commitment to excellence and confidentiality.